Showing posts with label Pharmacology. Show all posts
Showing posts with label Pharmacology. Show all posts

ASTHMA


Major Side Effects Nursing Intervention
albuterol, terbutaline (theophyline tremor dizziness palpitation -do not exceed prescribed dose -notify physician if client becomes non-responsive to usual dose
theophyline arrhythmias, seizures - monitor vital signs -maintenance: teach client to take at regular intervals during day
corticosteroids cushing's syndrome - do not discontinue abruptly (may trigger adrenal insufficiency crisis)

ANTIARRHTHMIC DRUGS

- all antiarrhythmics have the potential to worsen arrhythmia ->bradycardias, tachycardias, hypotension - instruct client to take exactly as prescribed


Major Side Effects Nursing Intervention
procainamide reversible lupus erythematosus -discontinue, under medical supervision if lupus occurs
phenytoin gingival hyperplasia -teach client proper mouth and dental care
quinidine potentiates digitoxin toxicity -monitor apical heart rate and blood pressure -monitor ECG

ANTICOAGULANTS


Antagonist (in case of Overdose) Nursing Interventions
heparin (immediate effect) protamine sulfate -do not give IM(hematoma and pain) -watch for bleeding, bruises -teach client to avoid aspirin -monitor partial thromboplastin time (PTT)
warfarin (takes 4-5 days for full effect) oral vitamin k -watch for bleeding, bruises -teach client to avoid aspirin -if ongoing therapy: client should carry medical alert card -monitor prothrombin time (PT)
streptokinase, urokinase (to dissolve thrombi) aminocaproic acid -risk of severe bleeding have blood available for transfusion

INOTROPIC DRUGS

- increased strength of cardiac contraction -> increased stroke volume -> increased cardiac output


Major Side Effects Nursing Intervention
digoxin, digitoxin low therapeutic index!!! (= high risk of toxicity -take apical pulse for full minute, monitor ECG -don't give if hearth rate is low (<60bpm) -monitor potassium levels (risk of enhanced toxicity)
dobutamine, dopamine hypertension, headache, angina -alert physician if arrhythmia, chest pain or dyspnea occur
extracardiac: -nausea, abdominal pain -fatigue -confusion, disorientation -color misperception: yellow halos cardiac: - AV block, arrhythmias Toxicity of DIGITALIS is enhanced by: >hypokalemia >alkalosis >hypoxia

DIURETICS


Major Side Effects Nursing Intervention
furosemide (loop diuretics) hypokalemia -recommend foods rich in potassium: bananas, prunes... -watch for signs of hypokalemia: muscle weakness, cramps
thiazides hypokalemia hyperglycemia -recommend foods rich in potassium: bananas, prunes... -watch for signs of hypokalemia: muscle weakness, cramps -monitor blood glucose
spirinolactone (potassium sparing) gynecomastia menstrual irregularity -clients need to be advised of possible endocrine effects -teach client to avoid excessive dietary potassium
mannitol (osmotic diuretic) transient plasma volume increase -monitor vital signs and central venous pressure
potensiates digitalis toxicity .

NITRITES


Major Side Effects Nursing Intervention
nitroglycerin. ISDN headache, dizziness orthostatic hypotension -occasional headache: aspirin or acetaminophen -frequent headache: may have to adjust dosage -instruct client to rise slowly from sitting position -instruct client to protect drug from light, heat and moisture

ANTIHYPERTENSIVE DRUGS


Contraindications Nursing Interventions
propranolol (beta-blockers) diabetes asthma peripheral vascular disease -watch client: dizziness and fatigue increase risk of injury -advice client not to discontinue abruptly -risk of rebound hypertension, angina or MI
nifedipine (Ca2+ antagonists) congestive heart failure -advice clients not to discontinue abruptly
captopril (ACE inhibitor) pregnancy -advice client to stand up slowly (orthostatic hypotension is a common problem)

CORTICOSTEROIDS


Major Side Effects Nursing Interventions
cortizone, dexamethazone cushing's syndrome, adrenal depression, skin atrophy CREAMS: -do not apply to broken skin -don't apply near eyes SYSTEMIC: -monitor for edema, signs of infection -avoid immobility (increased risk of osteoporosis) -never discontinue abruptly (taper the dose)

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS

> NSAIDs inhibit prostaglandin synthesis and may cause erosive gastritis and bleeding. Discourage "routine" use.


Major side effects
Nursing Interventions
aspirin
GI distress, occult bleeding suppresses platelet function may cause Raye's syndrome
-give with meals or milk
-dont give within 1 week of surgery (risk of bleeding)
-dont give with children with viral infection

acetaminophen
liver toxicity with overdose
-monitor liver enzymes for 1 week in case of overdose

ibuprofen
GI distress
-give with meals or milk

phenylbytazone
bone marrow depression, anemia
-monitor CBC
-should not be used for more than 1 week

indomethacin
CNS: dizziness, lightheadedness, blurred vision
-regular eye exam if used for long term therapy


signs of salicylate intoxications:
mild- tinnitus, central hyperventilation
severe- respiratory plus metabolic acidosis

Reye's syndrome:
avoid aspirin in children with viral infection
rish for fulminant hepatitis, cerebral edema
-Haunurses 5/14/08 3:42 PM

ANTIBIOTICS

>antibiotics may cause diarrhea due to disruption of normal flora.


Major side effects
Nursing Interventions
penicillins
allergic reactions:
-maculopapular rash
-anaphylactic shock
-watch for rash, fever and chills
-be prepared to treat anaphylaxis.

cephalosporins
allergic reactions
-check patient history: avoid in patients with known penicillin allergy

sulfonamides
renal toxicity
-best absorbed on empty stomach
-increase fluid intake

aminoglycosides
renal toxicity
ototoxicity
-increase fluid intake
-watch for tinnitus, vertigo or hearing loss

tetracyclines
bind with calcium
-give at least 2 hours before or after ingesting milk.
-dont give in 2nd half of pregnancy or to children <8years
(->tooth discoloration)

isoniazid
(antitubercular)
hepatotoxicity
peripheral neuropathy
-watch for loss of appetite, jaundice, dark urine
-monitor liver function test
-avoid alcohol

rifampicin
(antitubercular)
hepatotoxicity
orange color urine
-teach client that orange urine coloration is normal effect

ethambutol
(antitubercular)
impaired vision
-evaluate clients vision and color discrimination

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